Article

FASN Inactivation-Induced Progranulin (GRN) Expression Promotes Lysosome-Dependent Cell Death to Suppress Leukemogenesis

2025-05-10

Abstract excerpt

Cancer cells rely on lipogenesis in addition to exogenous lipid uptake, and fatty acid synthase (FASN) is aberrantly overexpressed in myeloid leukemia. However, the precise role of FASN in leukemogenesis in vivo remains elusive. Here, we demonstrated that FASN is essential for leukemogenesis. Ablation of FASN impeded leukemic cell growth, survival, clonogenicity in vitro , and the leukemic burden in vivo . Cond...

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Literature Corpus work: 585121ba-7461-5bdf-adb4-a982d83e62a3
DOI: 10.1101/2025.05.06.652401

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FASN Inactivation-Induced Progranulin (GRN) Expression Promotes Lysosome-Dependent Cell Death to Suppress LeukemogenesisDOI 10.1101/2025.05.06.652401Read

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