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Article

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.

EMBO molecular medicine - 1 Mar 2018

Ali Azhar, Levantini Elena, Teo Jun Ting, Goggi Julian, Clohessy John G, Wu Chan Shuo, Chen Leilei, Yang Henry, Krishnan Indira, Kocher Olivier, Zhang Junyan, Soo Ross A, Bhakoo Kishore, Chin Tan Min, Tenen Daniel G

Abstract excerpt

Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cells to sustain survival signals. In this report, we describe a novel oncogenic signaling pathway exclusively acting in mutated epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) with acquired tyrosine kinase inhibitor (TKI) resistance. Mutated EGFR mediates TKI resistance through regulation of...

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Identifiers

PMID: 29449326
DOI: 10.15252/emmm.201708313
PMCID: PMC5840543

Genes

EGFR
FASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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