Article
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia.
Cancer discovery - 7 Jul 2023
Sabatier Marie, Birsen Rudy, Lauture Laura, Mouche Sarah, Angelino Paolo, Dehairs Jonas, Goupille Léa, Boussaid Ismael, Heiblig Maël, Boet Emeline, Sahal Ambrine, Saland Estelle, Santos Juliana C, Armengol Marc, Fernández-Serrano Miranda, Farge Thomas, Cognet Guillaume, Simonetta Federico, Pignon Corentin, Graffeuil Antoine, Mazzotti Céline, Avet-Loiseau Hervé, Delos Océane, Bertrand-Michel Justine, Chedru Amélie, Dembitz Vilma, Gallipoli Paolo, Anstee Natasha S, Loo Sun, Wei Andrew H, Carroll Martin, Goubard Armelle, Castellano Rémy, Collette Yves, Vergez François, Mansat-De Mas Véronique, Bertoli Sarah, Tavitian Suzanne, Picard Muriel, Récher Christian, Bourges-Abella Nathalie, Granat Fanny, Kosmider Olivier, Sujobert Pierre, Colsch Benoit, Joffre Carine, Stuani Lucille, Swinnen Johannes V, Guillou Hervé, Roué Gael, Hakim Nawad, Dejean Anne S, Tsantoulis Petros, Larrue Clément, Bouscary Didier, Tamburini Jerome, Sarry Jean-Emmanuel
Abstract excerpt
Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely unknown in cancer. Here, multiomics analyses uncovered a coordinated activation of C/EBPα and Fms-like tyrosine kinase 3 (FLT3) that increased lipid anabolism in vivo and in patients with FLT3-mutant acute myeloid leukemia (AML)....
Topics
Join the communities discussing this publication.