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Article

Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017

Li Chien-Feng, Fang Fu-Min, Chen Yen-Yang, Liu Ting-Ting, Chan Ti-Chun, Yu Shih-Chen, Chen Li-Tzong, Huang Hsuan-Ying

Abstract excerpt

Purpose: In gastrointestinal stromal tumors (GIST), lipid-metabolizing enzymes remain underexplored, including fatty acid synthase (FASN).Experimental Design: Forty GISTs were quantitated for FASN mRNA abundance. FASN immunoexpression was informative in 350 GISTs, including 213 with known KIT/PDGFRA/BRAF genotypes. In imatinib-resistant FASN-overexpressing GIST cells, the roles of overexpressed FASN and...

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Source

Identifiers

PMID: 28442505
DOI: 10.1158/1078-0432.CCR-16-2770

Genes

FASN
KIT
BRAF
PDGFRA
RPS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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