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Article

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy

2020-01-30

Abstract excerpt

Fatty acid synthase (FASN) is the only human lipogenic enzyme available for de novo fatty acid synthesis and is often highly expressed in cancer cells. We found that FASN mRNA levels were significantly higher in acute myeloid leukemia (AML) patients than in healthy granulocytes or CD34 + hematopoietic progenitors. Accordingly, FASN levels decreased during all- trans retinoic acid (ATRA)-mediated granulocytic di...

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Literature Corpus work
90089190-09fe-5d02-8e2a-d4b101bd6a9f
DOI
10.1101/2020.01.29.924555
Open publication

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Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapyDOI 10.1101/2020.01.29.924555
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