Article

Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model

2018-05-30

Abstract excerpt

<h4>ABSTRACT</h4> We use a computational modelling approach to explore whether it is possible to infer a tumour’s cell proliferative hierarchy, under the assumptions of the cancer stem cell hypothesis and neutral evolution. We focus on inferring the symmetric division probability for cancer stem cells in our model, as this is believed to be a key driving parameter of tumour progression and therapeutic response. G...

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Identifiers and source

Literature Corpus work: 98e83ee1-8840-5b51-85f3-560d2b1f607c
DOI: 10.1101/334946

Open publication

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