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Article

Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors.

PLoS computational biology - 1 May 2011

Sottoriva Andrea, Vermeulen Louis, Tavaré Simon

Abstract excerpt

The cancer stem cell (CSC) concept is a highly debated topic in cancer research. While experimental evidence in favor of the cancer stem cell theory is apparently abundant, the results are often criticized as being difficult to interpret. An important reason for this is that most experimental data that support this model rely on transplantation studies. In this study we use a novel cellular Potts model to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21573198
DOI: 10.1371/journal.pcbi.1001132
PMCID: PMC3088646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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