Article
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
2019-02-08
Abstract excerpt
Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth that accounts for somatic mutations, selection, drift and spatial constrains, to simulate multi-region sequencing data derived from spatial sampling of a neoplasm. We show that the spatial stru...
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Identifiers and source
- Literature Corpus work
- 702d2667-f1dc-5b65-8b41-499d4269ac24
- DOI
- 10.1101/544536