Article

Spatial structure governs the mode of tumour evolution

2019-03-23

Abstract excerpt

Characterizing the mode – the way, manner, or pattern – of evolution in tumours is important for clinical forecasting and optimizing cancer treatment. DNA sequencing studies have inferred various modes, including branching, punctuated and neutral evolution, but it is unclear why a particular pattern predominates in any given tumour. 1, 2 Here we propose that differences in tumour architecture alone can explain th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b8b379e-8833-5e8b-9574-066c9987259a
DOI: 10.1101/586735

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial structure governs the mode of tumour evolutionDOI 10.1101/586735Read

Tumor evolution: Linear, branching, neutral or punctuated?Semantic proximity Read

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity.Semantic proximity Read

Classifying the evolutionary and ecological features of neoplasms.Semantic proximity Read

Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneitySemantic proximity Read

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic dataSemantic proximity Read

Cancer Evolution and the Limits of Predictability in Precision Cancer MedicineSemantic proximity Read

Between-region genetic divergence reflects the mode and tempo of tumor evolution.Semantic proximity Read

Cancer evolution and heterogeneitySemantic proximity Read

Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.Semantic proximity Read

When, why and how clonal diversity predicts future tumour growthSemantic proximity Read

Evolutionary dynamics and molecular features of intra-tumor heterogeneitySemantic proximity Read

Spatial mutation patterns as markers of early colorectal tumor cell mobility.Semantic proximity Read