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Article

Advances in understanding tumour evolution through single-cell sequencing.

Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2017

Kuipers Jack, Jahn Katharina, Beerenwinkel Niko

Abstract excerpt

The mutational heterogeneity observed within tumours poses additional challenges to the development of effective cancer treatments. A thorough understanding of a tumour's subclonal composition and its mutational history is essential to open up the design of treatments tailored to individual patients. Comparative studies on a large number of tumours permit the identification of mutational patterns which may refine...

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Share to Adaptation, Physiological
Share to Biomarkers, Tumor
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 28193548
DOI: 10.1016/j.bbcan.2017.02.001
PMCID: PMC5813714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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