Article

Hypoxia increases the tempo of evolution in glioblastoma

2018-04-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Low oxygen in tumours have long been associated with poor prognosis and metastatic disease, precise reasons for which remain poorly understood. Somatic evolution drives cancer progression and treatment resistance. This process is fuelled not only by genetic and epigenetic mutation, but by selection resulting from the interactions between tumour cells, normal cells and physic...

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Literature Corpus work: ecede66b-d8ac-52d9-a52e-880d64d0f3d6
DOI: 10.1101/293712

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