Article

Estimating stem cell fractions in hierarchically organized tumors

2015-01-11

Abstract excerpt

Cancers arise as a result of genetic and epigenetic alterations. These accumulate in cells during the processes of tissue development, homeostasis and repair. Many tumor types are hierarchically organized and driven by a sub-population of cells often called cancer stem cells. Cancer stem cells are uniquely capable of recapitulating the tumor and can be highly resistant to radio-and chemotherapy treatment. We inves...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1f004ac-fa06-51e7-89de-f178611a8898
DOI: 10.1101/013672

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Estimating stem cell fractions in hierarchically organized tumorsDOI 10.1101/013672Read

Cancer stem cells: small subpopulation or evolving fraction?Semantic proximity Read

Determinants of stem cell enrichment in healthy tissues and tumors: implications for non-genetic drug resistanceSemantic proximity Read

Non-stem cancer cell kinetics modulate solid tumor progressionSemantic proximity Read

Cancer Stem Cells: Models and ConceptsSemantic proximity Read

The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor RadioresponseSemantic proximity Read

Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell OrganizationSemantic proximity Read

Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation studySemantic proximity Read

Evolution and phenotypic selection of cancer stem cells.Semantic proximity Read

Discovery of the cancer stem cell related determinants of radioresistanceSemantic proximity Read

The therapeutic implications of plasticity of the cancer stem cell phenotype.Semantic proximity Read

Invincible, but not invisible: imaging approaches toward in vivo detection of cancer stem cells.Semantic proximity Read

Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical HeterogeneitySemantic proximity Read