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Article

Constrained optimization of divisional load in hierarchically organized tissues during homeostasis.

Journal of the Royal Society, Interface - 1 Feb 2022

Ashcroft Peter, Bonhoeffer Sebastian

Abstract excerpt

It has been hypothesized that the structure of tissues and the hierarchy of differentiation from stem cell to terminally differentiated cell play a significant role in reducing the incidence of cancer in that tissue. One specific mechanism by which this risk can be reduced is by minimizing the number of divisions-and hence the mutational risk-that cells accumulate as they divide to maintain tissue homeostasis....

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Identifiers

PMID: 35193391
DOI: 10.1098/rsif.2021.0784
PMCID: PMC8864360

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