Article

State-dependent evolutionary models reveal modes of solid tumor growth

2022-08-06

Abstract excerpt

Spatial properties of tumor growth have profound implications for cancer progression, therapeutic resistance and metastasis. Yet, how spatial position governs tumor cell division remains difficult to evaluate in clinical tumors. Here, we demonstrate that elevated cellular growth rates on the tumor periphery leave characteristic patterns in the genomes of cells sampled from different parts of a tumor, which become...

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Literature Corpus work: a9c1f4be-67f7-5c68-aed9-dfb64e18ba65
DOI: 10.1101/2022.08.05.502978

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