Article
Quantifying cell divisions along evolutionary lineages in cancer
2024-01-12
Abstract excerpt
<title>Abstract</title> <p>Cell division drives somatic evolution but is challenging to quantify in human tissues. Here, we develop a framework to count cell divisions with DNA replication-related mutations in polyguanine homopolymers. We apply the method in two different scenarios. First, analyzing 505 samples from 37 patients, we study the milestones of colorectal cancer evolution. We find that tumor founder ce...
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Identifiers and source
- Literature Corpus work
- a6cbd36e-442b-516d-8991-88a91d7d4635
- DOI
- 10.21203/rs.3.rs-3839927/v1