Article

Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation

2022-11-29

Abstract excerpt

Neuroproteasomes are a subset of 20S proteasomes that are localized to the neuronal plasma membrane and degrade newly synthesized proteins. To date, the molecular composition of neuroproteasomes is undefined, and moreover, whether neuroproteasomes can influence protein aggregation with relevance to neurodegenerative disorders remains unexplored. Using a Cre-dependent conditional knock-in mouse line to endogenously...

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Literature Corpus work: 98e23f17-d118-52c3-9745-d617260eeec3
DOI: 10.1101/2022.11.29.518293

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