Article

Proteostasis as a fundamental principle of Tau immunotherapy

2024-02-14

Abstract excerpt

The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localisation and a vast array of post-translational modifications including phosphorylation, that progressively result in the protein’s aggregation and dysregulation of multiple Tau-dependent cellular...

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Literature Corpus work: 9ff4a30e-0c6b-5193-b52b-f6aa194fd573
DOI: 10.1101/2024.02.12.580007

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