Article

APOE4 disrupts the central dogma by arresting neuronal proteome dynamics

2026-07-22

Abstract excerpt

<h4>SUMMARY</h4> Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease and promotes neuronal dysfunction through incompletely understood mechanisms. Here, we integrated transcriptomic, translatomic, and proteomic profiling of isogenic APOE3 and APOE4 human iPSC-derived neurons and found that APOE4 fundamentally impairs neuronal proteome renewal. Although transcriptional...

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Literature Corpus work: ee1f5538-6ca7-5d73-a307-aa8651f58d1b
DOI: 10.64898/2026.07.15.738801

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