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Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer’s disease

2026-06-28

Abstract excerpt

<h4>Introduction</h4> The proteasome is a critical cellular degradative machinery impaired in late-stage Alzheimer’s disease (AD). However, the status and activity of the proteasome in early-stage sporadic AD (sAD) is unknown. <h4>Methods</h4> A cellular model of human early-stage sAD was generated from sAD patient iPSC-derived cortical neurons by dual-SMAD inhibition. The iPSCs, neuroprogenitors, and cortical n...

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Literature Corpus work
10b7c29c-494f-5cda-b16a-fd7e4e817cd8
DOI
10.64898/2026.06.23.734021
Open publication

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Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer’s diseaseDOI 10.64898/2026.06.23.734021
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