Article
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature - 28 Sept 2017
Shi Yang, Yamada Kaoru, Liddelow Shane Antony, Smith Scott T, Zhao Lingzhi, Luo Wenjie, Tsai Richard M, Spina Salvatore, Grinberg Lea T, Rojas Julio C, Gallardo Gilbert, Wang Kairuo, Roh Joseph, Robinson Grace, Finn Mary Beth, Jiang Hong, Sullivan Patrick M, Baufeld Caroline, Wood Michael W, Sutphen Courtney, McCue Lena, Xiong Chengjie, Del-Aguila Jorge L, Morris John C, Cruchaga Carlos, Fagan Anne M, Miller Bruce L, Boxer Adam L, Seeley William W, Butovsky Oleg, Barres Ben A, Paul Steven M, Holtzman David M
Abstract excerpt
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. By generating P301S tau transgenic mice on either a human ApoE knock-in (KI) or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.