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Article

Associations of the LIBRA index with cognitive resilience to genetic susceptibility to dementia.

American journal of epidemiology - 3 Sept 2025

Wagner Maude, Neuffer Jeanne, Le Grand Quentin, Mishra Aniket, Berr Claudine, Debette Stéphanie, Helmer Catherine, Proust-Lima Cécile, Samieri Cécilia

Abstract excerpt

The role of lifestyle and health-related factors in dementia risk has been established. However, how a combination of modifiable risk factors, as reflected by the LIfestyle for BRAin health (LIBRA) index, contributes to cognitive resilience to genetic susceptibility to dementia (CRgen) remains unclear. We selected 6774 Three-City study participants without dementia at baseline (mean age = 74 years) and with ≥2...

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PMID: 40394208
DOI: 10.1093/aje/kwaf108

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