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Article

A novel approach to resilience and its links with education and Alzheimer's disease genetics.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2025

Carrigan Maria, Bocancea Diana I, Vogel Jacob, van Loenhoud Anna C, Tesi Niccoló, Barkhof Frederik, Lucassen Paul J, van der Flier Wiesje M, Krugers Harm J, Van der Lee Sven J, Ossenkoppele Rik

Abstract excerpt

INTRODUCTION: Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS: We analyzed amyloid-positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dementia Cohort (ADC, N = 1036) and Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 685). Cognitive resilience was conceptualized from a canonical correlation analysis of...

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Identifiers

PMID: 40613482
DOI: 10.1002/alz.70379
PMCID: PMC12231230

Genes

APOE
COX7C
MINDY2
TPCN1
UNC5CL
USP6NL

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