Article

Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach

2025-11-04

Abstract excerpt

Understanding how distinct neuronal subtypes contribute to Alzheimer’s disease (AD) pathology remains a major challenge. Patient-derived induced pluripotent stem cell (iPSC) studies have shown neuronal subtype-specific molecular and pathological signatures, yet the underlying metabolic shifts driving this selective vulnerability are not completely understood. Here we present iNeuron-GEM, the first manually curated...

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Literature Corpus work: 989d5363-2059-56a0-b1ec-309fada0ce0d
DOI: 10.1101/2025.11.03.686281

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