Article

Identifying neuron subtype-specific metabolic network changes in single cell transcriptomics of Alzheimer’s Disease using perturb-Met

2021-01-19

Abstract excerpt

Metabolic aberrations are a prominent feature of Alzheimer’s Disease (AD). Different neuronal subtypes have selective vulnerability in AD. Despite the recent advance of single cell and single nucleus RNA-seq of AD brains, genome-scale metabolic network changes in neuronal subtypes have not been systematically studied with detail. To bridge this knowledge gap, I developed a computational method called perturb-Met t...

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Literature Corpus work: f5e49ecb-d4e7-5dc1-8d9f-784e7628e805
DOI: 10.1101/2021.01.18.427154

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