Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s Disease

Abstract excerpt

Alzheimer’s disease (AD), a leading cause of dementia, has been recognized as a disease with profound metabolic dysregulation. However, a systems-level view of metabolic regulation across multiple omic modalities in AD remains elusive. Here, we integrated public multi-omic datasets (transcriptome, proteome, and metabolome) from the dorsolateral prefrontal cortex of AD patients and controls. By leveraging existing...

Topics

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• Alzheimer's disease research and treatments
• Bioinformatics and Genomic Networks
• Cholesterol and Lipid Metabolism
• Gut microbiota and health
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies
• Nutritional Studies and Diet
• Tryptophan and brain disorders

Identifiers and source

Literature Corpus work

4495502c-81f2-5a97-b857-d7163595b2ef

DOI

10.1101/2025.09.26.678758