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Article

Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap.

EBioMedicine - 1 May 2026

Stinson Sara E, Shadrin Alexey A, Rahman Zillur, Rødevand Linn, Broce Iris J, Selbæk Geir, Stefansson Hreinn, Haavik Jan, Parker Nadine, Koch Elise, Frei Oleksandr, O'Connell Kevin S, Smeland Olav B, Djurovic Srdjan, Dale Anders M, van der Meer Dennis, Andreassen Ole A

Abstract excerpt

BACKGROUND: Metabolic dysfunction is a major risk factor for neurodegeneration, yet the genetic architecture linking systemic metabolism to Alzheimer's disease (AD) and Parkinson's disease (PD) remains unclear. METHODS: We integrated genome-wide association data for 249 circulating metabolites and proglucagon with summary statistics for AD, PD, and cardiometabolic traits. Genetic correlations, polygenic overlap,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41966729
DOI: 10.1016/j.ebiom.2026.106254
PMCID: PMC13091360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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