Article

Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism

2021-07-01

Abstract excerpt

Starting with a comprehensive generic reconstruction of human metabolism, we generated high-quality, constraint-based, genome-scale, cell-type and condition specific models of metabolism in human dopaminergic neurons, the cell type most vulnerable to degeneration in Parkinson ’ s disease. They are a synthesis of extensive manual curation of the biochemical literature on neuronal metabolism, together with novel, q...

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Literature Corpus work: baca0567-cdf1-55c2-828c-4dfba2d1715b
DOI: 10.1101/2021.06.30.450562

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