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Article

Mechanisms of lysosomal tubulation and sorting driven by LRRK2.

Biochemical Society transactions - 28 Aug 2024

Bonet-Ponce Luis, Kluss Jillian H, Cookson Mark R

Abstract excerpt

Lysosomes are dynamic cellular structures that adaptively remodel their membrane in response to stimuli, including membrane damage. Lysosomal dysfunction plays a central role in the pathobiology of Parkinson's disease (PD). Gain-of-function mutations in Leucine-rich repeat kinase 2 (LRRK2) cause familial PD and genetic variations in its locus increase the risk of developing the sporadic form of the disease. We...

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Identifiers

PMID: 39083004
DOI: 10.1042/BST20240087
PMCID: PMC11668303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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