Article
Mechanisms of lysosomal tubulation and sorting driven by LRRK2.
Biochemical Society transactions - 28 Aug 2024
Bonet-Ponce Luis, Kluss Jillian H, Cookson Mark R
Abstract excerpt
Lysosomes are dynamic cellular structures that adaptively remodel their membrane in response to stimuli, including membrane damage. Lysosomal dysfunction plays a central role in the pathobiology of Parkinson's disease (PD). Gain-of-function mutations in Leucine-rich repeat kinase 2 (LRRK2) cause familial PD and genetic variations in its locus increase the risk of developing the sporadic form of the disease. We...
Topics
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes
- Humans
- Parkinson Disease
- Animals
- Phosphorylation
- rab GTP-Binding Proteins
- Protein Transport
- Mutation