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Article

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.

Current opinion in cell biology - 1 Apr 2020

Taylor Matthew, Alessi Dario R

Abstract excerpt

Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic efficacy of LRRK2 inhibitors is being tested in clinical trials. In this review, we discuss the nuts and bolts of our current understanding of how the LRRK2 is misregulated by mutations and how pathway activity is affected by LRRK2 binding to...

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Identifiers

PMID: 32036294
DOI: 10.1016/j.ceb.2020.01.001
PMCID: PMC7262585

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