Article

LRRK2/LRRK1 interactions modulate Rab7 activity and inhibit lysosomal exocytosis

2026-06-15

Abstract excerpt

Mutations in the LRRK2 gene are the most common genetic cause of both familial and sporadic Parkinson’s disease (PD). LRRK2 belongs to the leucine-rich repeat kinase (LRRK) family. Two members of the LRRK family exist in humans (LRRK1 and LRRK2). Although there is strong structural similarity between the two proteins, they have attracted very different levels of attention by the scientific community owing to the...

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Literature Corpus work: d7891980-0d00-5ca7-bf97-24c0e8bc223a
DOI: 10.64898/2026.06.12.731951

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