Article
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.
Nature cell biology - 1 Apr 2016
Li Xinran, Rydzewski Nicholas, Hider Ahmad, Zhang Xiaoli, Yang Junsheng, Wang Wuyang, Gao Qiong, Cheng Xiping, Xu Haoxing
Abstract excerpt
To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal Ca(2+) channel TRPML1 cause lysosomal storage disease (LSD) characterized by disordered lysosomal membrane trafficking in cells. Here we show that TRPML1 activity is required to promote Ca(2+)-dependent centripetal movement of lysosomes...
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