Article

Cell cycle-coupled transcriptional network orchestrates human B cell fate bifurcation

2025-04-24

Abstract excerpt

<h4>SUMMARY</h4> Antibody responses are determined by activated B cells bifurcating into plasmablasts (PBs) and germinal center B cells (GCBCs). Gene regulatory networks (GRNs) underlying human B cell fate choice remain uncharted. Temporally resolved single-cell multi-omics, computational modeling and CRISPR-based perturbations were used to assemble, simulate and test high-resolution GRNs underlying PB and GC fat...

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Literature Corpus work: 9869f9f0-52e6-5d95-8591-de267ae1d1de
DOI: 10.1101/2025.04.23.649973

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