Article

Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon

2026-06-19

Abstract excerpt

The transcription factors IRF4 and BLIMP1 ( PRDM1 ) promote plasma cell (PC) differentiation by repressing B cell identity genes while inducing the unfolded protein response, ER/Golgi biogenesis, and immunoglobulin secretion. How IRF4 and BLIMP1 partition and coordinate their genomic activities during plasma cell differentiation remains unresolved. Using naïve human B cells and a stepwise in vitro differentiatio...

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Literature Corpus work: 3147e68a-c9d5-50df-8b70-ffc468b9b57f
DOI: 10.64898/2026.06.15.732353

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