Article

Competing gene regulatory networks drive naive and memory B cell differentiation

2025-06-08

Abstract excerpt

Elucidating the gene regulatory networks (GRNs) that govern human B cell differentiation is essential for understanding immune responses to infection, vaccination and autoantigens. Here, we show that individual naive B cells can give rise to both plasma cells and germinal centre (GC) B cells. In contrast, memory B cells display a progressive increase in IRF4 activity over time, leading to PRDM1 induction and exclu...

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Literature Corpus work: d8029905-060b-5e8a-b6e6-3521aa3f2cdd
DOI: 10.1101/2025.06.04.657836

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