Article

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition

2025-09-01

Abstract excerpt

Germinal-center (GC) B-cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably Nr4a1 , are known. We reveal an unsuspected role for PRDM1 (BLIMP1), a plasma-cell determinant, as a feedback regulator of affinity maturation. Single cell RNA-seq and BCR-seq showed that B- cell–specific Prdm1 loss drives an exaggerated GC reaction with...

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Literature Corpus work: 9d806027-bb8e-522d-8ef8-05fe7b452279
DOI: 10.1101/2025.08.27.672737

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PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transitionDOI 10.1101/2025.08.27.672737Read

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