Article

Predictive control of human pancreatic cell fate using a digital model of <i>in vitro</i> differentiation

2026-04-30

Abstract excerpt

<h4>SUMMARY</h4> The controlled generation of mature stem cell-derived islets (SC-islets) remains a barrier to scalable cell therapy for diabetes. Here, we develop a predictive digital model defining the cell-state-specific regulatory logic governing fate specification during human SC-islet differentiation. We integrate 400,603 cells from 9 original single-cell multiomic datasets and 52 public single-cell RNA-seq...

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Literature Corpus work: 6794d850-2911-5af4-b513-75b7150369cf
DOI: 10.64898/2026.04.27.721124

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