Article

IFNγ-induced IRF1 synergizes with TLR7 signals to tune the IRF4-IRF8 axis and drive pathogenic effector B cell fate

2026-02-09

Abstract excerpt

<h4>SUMMARY</h4> Interferon regulatory factor 1 (IRF1), a transcription factor encoded within the 5q31 locus harboring systemic lupus erythematosus (SLE) associated variants, promotes inflammatory responses by T and myeloid cells. Although IFNγ-activated B cells also express IRF1, its role in B cell biology and SLE is unclear. Here, we use a mouse SLE model, single-cell multiomics, and human B cells to show that...

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Literature Corpus work: 0dfb8602-1297-5670-af5b-671a822ea492
DOI: 10.64898/2026.02.06.704376

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