Article

Structural Impact of Alzheimer’s Disease Mutations on Transmembrane TREM2-DAP12 Interactions: An Atomistic Perspective

2025-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunomodulatory receptor that plays a critical role in microglial activation through its association with the adaptor protein DNAX-activation protein 12 (DAP12). Genetic studies have identified rare TREM2 variants as key risk factors for Alzheimer’s disease (AD), with mutations affecting both the extracellular and transmembrane doma...

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Literature Corpus work: 66fd5758-2b7e-5fd9-8c06-c8e4003ee75c
DOI: 10.1101/2025.06.26.661739

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