Article

APOE ɛ4, but not polygenic AD risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals

2022-10-17

Abstract excerpt

The hippocampus is early affected in Alzheimer’s Disease (AD) and altered hippocampal functioning influences normal cognitive aging. Here, we used functional MRI to assess if the APOE ɛ4 allele or a polygenic risk score (PRS) for AD was linked to longitudinal changes in memory-related hippocampal activation also in normal aging (baseline age 50–95, n = 292; n = 182 at four-year follow-up, subsequently non-demented...

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Literature Corpus work: 97c97478-f74b-55a2-af2e-3043a234adc0
DOI: 10.21203/rs.3.rs-2157776/v1

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