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Article

APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD.

PloS one - 1 Jan 2014

Manning Emily N, Barnes Josephine, Cash David M, Bartlett Jonathan W, Leung Kelvin K, Ourselin Sebastien, Fox Nick C

Abstract excerpt

OBJECTIVES: To investigate whether APOE ε4 carriers have higher hippocampal atrophy rates than non-carriers in Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brain atrophy rates. METHODS: MRI scans from all available visits in ADNI (148 AD, 307 MCI, 167 controls) were used. MCI...

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Source

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Identifiers

PMID: 24878738
DOI: 10.1371/journal.pone.0097608
PMCID: PMC4039513

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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