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Article

Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan

8 Sept 2020

Abstract excerpt

Objective To test the hypothesis that genetic risk for Alzheimer disease (AD) may represent a stable influence on the brain from early in life, rather than being primarily age dependent, we investigated in a lifespan sample of 1,181 persons with a total of 2,690 brain scans, whether higher polygenic risk score (PGS) for AD and presence of APOE ε4 was associated with lower hippocampal volumes to begin with, as an...

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PMID: 33134508
DOI: 10.1212/nxg.0000000000000506

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