Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE ɛ4, but not polygenic Alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals.

Scientific reports - 24 May 2023

Håglin Sofia, Koch Elise, Schäfer Hackenhaar Fernanda, Nyberg Lars, Kauppi Karolina

Abstract excerpt

The hippocampus is affected early in Alzheimer's disease (AD) and altered hippocampal functioning influences normal cognitive aging. Here, we used task-based functional MRI to assess if the APOE ɛ4 allele or a polygenic risk score (PRS) for AD was linked to longitudinal changes in memory-related hippocampal activation in normal aging (baseline age 50-95, n = 292; n = 182 at 4 years follow-up, subsequently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Hippocampus

Source

Open in PubMed Open full text

Identifiers

PMID: 37225733
DOI: 10.1038/s41598-023-35316-z
PMCID: PMC10209089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE ɛ4, but not polygenic Alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals.PMID 37225733Read ↗

APOE ɛ4, but not polygenic AD risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individualsSemantic proximity Read ↗

Genetic risk for Alzheimer’s disease predicts hippocampal volume through the lifespanSemantic proximity Read ↗

Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.Semantic proximity Read ↗

Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition.Semantic proximity Read ↗

Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Semantic proximity Read ↗

Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespanSemantic proximity Read ↗

Age-related polygenic effects of Alzheimer's disease on brain structures and cognition in middle aged and elderly adults from UK BiobankSemantic proximity Read ↗

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Semantic proximity Read ↗

Genetic Risk for Alzheimer's Disease Moderates the Association Between Medial Temporal Lobe Volume and Episodic Memory Performance Among Older Adults.Semantic proximity Read ↗

Genetic drivers of hippocampal atrophy highlight the role of<i>APOE</i>functional variants and AD polygenicity in Mild Cognitive ImpairmentSemantic proximity Read ↗

APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD.Semantic proximity Read ↗

Hippocampal volumes in UK Biobank are associated with APOE only in older adultsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.