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Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants

2020-10-27

Abstract excerpt

Hippocampal volume is an important biomarker of Alzheimer’s disease (AD), and genetic risk of AD is associated with hippocampal atrophy. However, the hippocampus is not a uniform structure and has a number of subfields, the associations of which with age, sex, and polygenic risk score for AD (PRS AD ) have been inadequately investigated. We examined these associations in 17,161 cognitively normal UK Biobank partic...

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Literature Corpus work
e0744de6-dacb-5689-a0b7-dbe87240cb9d
DOI
10.1101/2020.10.24.20218925
Open publication

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Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participantsDOI 10.1101/2020.10.24.20218925
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