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Age-related polygenic effects of Alzheimer's disease on brain structures and cognition in middle aged and elderly adults from UK Biobank

2024-05-03

Abstract excerpt

<title>Abstract</title> <p>The aetiology of Alzheimer’s disease (AD) involves multiple genes and their interactions, and the polygenetic risk score for AD (AD-PRS) offers a genome-wide assessment of an individual's risk for developing AD. Despite previous suggestions of the polygenic influences on brain structures in cognitively intact ageing populations, the dynamic effects of the AD-PRS on brain structures and...

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Literature Corpus work
29337cc8-3be5-56ec-ac52-6c1270c4b7bd
DOI
10.21203/rs.3.rs-4242200/v1
Open publication

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