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Cross-tissue transcriptome-wide association studies of 885,176 individuals and seven diseases of the gut-brain axis identify susceptibility genes shared between schizophrenia and inflammatory bowel disease

2021-07-15

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<title>Abstract</title> <p>Genetic correlations and an increased incidence of psychiatric disorders in inflammatory-bowel disease (IBD) have been reported, but shared molecular mechanisms are unknown. We performed cross-tissue and multiple-gene conditioned transcriptome-wide association studies (TWAS) for 23 tissues of the gut-brain-axis (GBA) using GWAS data sets (total 246,772 patients and 638,454 controls) for...

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Literature Corpus work
97c6a6cc-1e8c-520b-b462-09ce00db37b1
DOI
10.21203/rs.3.rs-590423/v1
Open publication

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Cross-tissue transcriptome-wide association studies of 885,176 individuals and seven diseases of the gut-brain axis identify susceptibility genes shared between schizophrenia and inflammatory bowel diseaseDOI 10.21203/rs.3.rs-590423/v1
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