Back to search

Article

Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interaction

2023-06-05

Abstract excerpt

Disorders of gut-brain interaction (DGBIs), formerly known as functional gastrointestinal disorders, are extremely common and historically difficult to manage. This is largely because their cellular and molecular mechanisms have remained poorly understood and understudied. One approach to unravel the molecular underpinnings of complex disorders such as DGBIs is performing genome wide association studies (GWASs). H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
14c2f280-f8de-550c-8a2d-36e6df77e967
DOI
10.1101/2023.06.02.23290906
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interactionDOI 10.1101/2023.06.02.23290906
Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disordersSemantic proximity
150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibilitySemantic proximity
Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases.Semantic proximity
Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous systemSemantic proximity
GWAS of stool frequency reveals genes, pathways, and cell types relevant to human gastrointestinal motility and irritable bowel syndromeSemantic proximity
Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic studySemantic proximity
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.Semantic proximity
Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotilitySemantic proximity
Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hitsSemantic proximity
Systematic analyses of GWAS summary statistics from UK Biobank identified novel susceptibility loci and genes for upper gastrointestinal diseases.Semantic proximity
Cross-tissue transcriptome-wide association studies of 885,176 individuals and seven diseases of the gut-brain axis identify susceptibility genes shared between schizophrenia and inflammatory bowel diseaseSemantic proximity
Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.Semantic proximity
Select a neighboring publication to make it the new centre.