Article

Rare Comorbidity between Inflammatory Bowel Disease and Primary Biliary Cholangitis: Evidence from Causality, Shared Genetic Architecture and Transcriptomics

2023-03-03

Abstract excerpt

<h4>Background</h4> Clinical studies have found comorbidity between Inflammatory Bowel Disease (IBD) and primary sclerosing cholangitis (PSC). Primary biliary cholangitis (PBC) is another autoimmune liver disease but the coexistence of IBD and PBC is rare. Whether there exists comorbidity between IBD and PBC and potential mechanism remains unclear. <h4>Methods</h4> We assessed the casual effect between PBC and IBD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dd745ec-f19f-5115-a64d-88834b6471bd
DOI: 10.1101/2023.03.01.23286611

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rare Comorbidity between Inflammatory Bowel Disease and Primary Biliary Cholangitis: Evidence from Causality, Shared Genetic Architecture and TranscriptomicsDOI 10.1101/2023.03.01.23286611Read

Integrative analysis of genetic and cellular interactions connecting inflammatory bowel disease and primary biliary cholangitis.Semantic proximity Read

Epidemiologic and genetic associations between primary biliary cholangitis and extrahepatic rheumatic diseases.Semantic proximity Read

Bioinformatics Analysis Reveals shared molecular pathways for Relationship between Ulcerative Colitis and Primary Sclerosing CholangitisSemantic proximity Read

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.Semantic proximity Read

Inflammatory Bowel Disease and Neurodegenerative Disorders: Integrated Evidence from Mendelian Randomization, Shared Genetic Architecture and TranscriptomicsSemantic proximity Read

An atlas of the shared genetic architecture between atopic and gastrointestinal diseases.Semantic proximity Read

Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization.Semantic proximity Read

Extraintestinal manifestations and complications in inflammatory bowel disease: from shared genetics to shared biological pathways.Semantic proximity Read

Cross-tissue transcriptome-wide association studies of 885,176 individuals and seven diseases of the gut-brain axis identify susceptibility genes shared between schizophrenia and inflammatory bowel diseaseSemantic proximity Read

Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk lociSemantic proximity Read

Investigating the shared genetic architecture between inflammatory bowel disease and pancreatitis: a genome-wide cross-trait analysis.Semantic proximity Read

A multilevel analysis of the genetic association between inflammatory bowel disease and primary sclerosing cholangitis.Semantic proximity Read