Article
Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Jan 2025
Zhu Zijun, Wei Rongxing, Li Hailong, Wang Xin, He Guanzhi, Du Meiyu, Tan Senwei, Cheng Liang
Abstract excerpt
Inflammatory bowel disease (IBD) with the two predominant endophenotypes-Crohn's disease (CD) and ulcerative colitis (UC)-represents a group of chronic gastrointestinal inflammatory conditions. Since most genetic associations with IBD are often limited to independent subtypes, we reported a genome-wide association study (GWAS) cross-trait analysis combined with CD and UC to enhance statistical power. Initially,...
Topics
Join the communities discussing this publication.