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Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders

14 Jan 2025

Abstract excerpt

Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic and transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) and weighted gene co-expression network analysis (WGCNA) to explore shared mechanism between psychiatric and gastrointestinal disorders. Significant genetic correlations were found between these disorders, especially in...

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PMID: 39809838
DOI: 10.1038/s42003-025-07481-6

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