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Article

Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases.

Brain and behavior - 1 Feb 2026

Zhao Ning, Tan Shiheng, Fu Qingzhen, Li Yanbing, Tian Tian, Cheng Zesong, Zhang Ding, Gao Lijing, Bao Weiwei, Zhang Depei, Li Zinan, Liu Jinyin, Wang Liwan, Zhang Zhuobo, Wang Fan, Zhao Yashuang

Abstract excerpt

BACKGROUND: The "gut-brain axis" provides a theoretical foundation for the connection between intestinal and neurological diseases, but whether this reflects a shared genetic etiology or causal relationships exist remains unclear. METHODS: We used genome-wide association study summary data from FinnGen and UK Biobank to investigate the genetic correlations and causal relationships between three intestinal...

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Identifiers

PMID: 41699864
DOI: 10.1002/brb3.71269
PMCID: PMC12910125

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